26 research outputs found
Habitual entrepreneurs in the making: how labour market rigidity and employment affects entrepreneurial re-entry
Full text linkChest imaging within the radiology department by means of photostimulable phosphor computed radiography: A review
No full textEvolution of convective systems across Hangzhou Bay during a sea-breeze-effect thunderstorm event
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Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males
No full textTherapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial
No full textInhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease
Get PDFHuntington's disease is a devastating neurodegenerative condition for which there is no therapy to slow disease progression. The particular vulnerability of striatal medium spiny neurons to Huntington's pathology is hypothesized to result from transcriptional dysregulation within the cAMP and CREB signaling cascades in these neurons. To test this hypothesis, and a potential therapeutic approach, we investigated whether inhibition of the striatal-specific cyclic nucleotide phosphodiesterase PDE10A would alleviate neurological deficits and brain pathology in a highly utilized model system, the R6/2 mouse
Association between frailty and chronic pain among older adults: a systematic review and meta-analysis
No full textDo Flexible Goal Adjustment and Acceptance Help Preserve Quality of Life in Patients with Multiple Sclerosis?
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